Ubiquitin: Same Molecule, Different Degradation Pathways

Ubiquitin: Same Molecule, Different Degradation Pathways

Ubiquitin is a common demoninator in the targeting of substrates to all three major protein degradation pathways in mammalian cells: the proteasome, the lysosome, and the autophagosome. The factors that direct a substrate toward a particular route of degradation likely include ubiquitin chain length and linkage type, which may favor interaction with particular receptors or confer differential s...

Phospholipids of Five Pseudomonad Archetypes for Different Toluene Degradation Pathways

Liquid chromatography/electrospray ionization/mass spectrometry (LC/ESI/MS) was used to determine intact phospholipid profiles for five reference pseudomonad strains harboring different (aerobic) toluene catabolic pathways: Pseudomonas putida mt-2, Pseudomonas putida F1, Burkholderia cepacia G4, Burkholderia pickettii PKO1, and Pseudomonas mendocina KR1. These five strains contained a predomina...

Ubiquitin-dependent mitochondrial protein degradation.

Progressive mitochondrial failure is tightly associated with the onset of many age-related human pathologies. This tight connection results from the double-edged sword of mitochondrial respiration, which is responsible for generating both ATP and ROS, as well as from risks that are inherent to mitochondrial biogenesis. To prevent and treat these diseases, a precise understanding of the mechanis...

Ubiquitin-Proteasome Degradation Pathway Tyrosine Kinase Level by Activating the The Adaptor Molecule CIN85 Regulates Syk

Same Programme, Different Students: Same or Different Self-efficacy Effects?

Objectives and Prior Work The relationship between self-efficacy and entrepreneurial intentions, opportunity recognition and career persistence is well established in the entrepreneurship literature. In addition to being a predictor of entrepreneurial behaviour, an individual's level of entrepreneurial self-efficacy (ESE) has repeatedly been shown to have a lasting legacy on venture growth and ...